See this image and copyright information in PMC. Zhang J.C., Dai J.Y., Fan J., Wu X.P. It works to treat bacterial infections when penicillin is not an option. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A 47-year-old female patient with multiple comorbidities was diagnosed with Sweet's Syndrome. Meadowcroft AM, Diaz PR, Latham GS. Please enable it to take advantage of the complete set of features! Hof H., Schnlle P. Pneumocystis jiroveci pneumonia in a patient with Wegener's granulomatosis treated efficiently with caspofungin. Clindamycin is an antibiotic that stops the growth of acne-causing bacteria. An intriguing correlation between the use of topical clindamycin and the improvement of CCLE was observed. Edman J.C., Kovacs J.A., Masur H., Santi D.V., Elwood H.J., Sogin M.L. This product is available in the following dosage forms: Powder for Solution May not be suitable for some people including those with a history of gastrointestinal disease (such as colitis) or a history of allergic reactions. Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Helweg-Larsen J., Benfield T., Atzori C., Miller R.F. Clindamycin-induced Maculopapular Exanthema with Preferential - PubMed Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Federal government websites often end in .gov or .mil. Injectable clindamycin contains 9.45mg of benzyl alcohol, which may be toxic to children in large amounts and cause a potentially fatal "gasping syndrome"). the TMP/SMZ due to nausea. Her past clinical history included hypertension, hypothyroidism, hyperuricemia, cholecystectomy, caesarean section, and endometriosis-related abdominal surgery, and she was taking levothyroxine, allopurinol, imidapril, and omeprazole. Show More Uses Clindamycin is used to treat a wide variety of bacterial infections. Epub 2021 Dec 15. It dropped to 89 pg/ml after 24 days of admission, indicating the success of treatment. Paquet P, Schaaflafontaine N, Pierard GE. Clindamycin does not treat infections caused by viruses, such as a cold or the flu. Its major disadvantage is its propensity to cause antibiotic-associated diarrhea, including Clostridioides difficile colitis. 1995;132:665-6. C column CT image displays a remarkable improvement after 22 days of the combined therapy. Ann Pharmacother. The treatment of pneumocystis Carinii pneumonia with caspofungin in elderly patients: a case report and literature review. Nevertheless, the efficacy of the new strategy is still uncertain. It works by slowing or stopping the growth of bacteria. A possible contributor to this clearance may have been a change in the patient's exposure to sunlight. The patient's LDH decreased to 877 U/L on day 8, and chest CT scan demonstrated that the lung lesions had decreased in size (Fig. Consult your doctor for more details. For serious anaerobic infections, the parenteral route is usually used initially but should be switched to the oral route as soon as the patient's condition allows. Approximately 20 days ago, the patient appeared intermittent fever after catching cold, and the temperature peak was about 38.0C. A patient with chronic cutaneous lupus Thus we cannot ignore the possibility of TMP/SMZ resistance despite the lack of reports on the mutation rates in China. Clindamycin systemic 300 mg (RX693 RX693). FOIA Clin Rev Allergy Immunol. The most important thing is to find safer and more effective alternatives for patients who are intolerant or resistant to TMP/SMZ. You may report them to the FDA. Wilson DH. official website and that any information you provide is encrypted AJN: provided text to the case report. Biosci Rep. 2019 Dec 20;39(12):BSR20193266. the contents by NLM or the National Institutes of Health. health information, we will treat all of that information as protected health Older adults may be more sensitive to the effects of this drug, especially diarrhea. Milstone EB, McDonald AJ, Scholhamer CF Jr. Pseudomembranous colitis after topical application of clindamycin. Call your doctor for medical advice about side effects. If you need help in planning the best times to take your medicine, check with your doctor. 2011 Mar-Apr;28(2):205-7. doi: 10.1111/j.1525-1470.2010.01249.x. Clindamycin is in a class of medications called lincomycin antibiotics. 16. Ann Intern Med. birth control treatments, such as estradiol, levonorgestrel, bowel cleansing agents such as sodium picosulfate, CYP3A4 inducers, such as erythromycin, diltiazem, itraconazole, ritonavir, or verapamil, neuromuscular blocking agents, such as atracurium or vecuronium. Subsequently upon discharge, the patient was also treated with rifampicin and azathioprine. You may opt-out of email communications at any time by clicking on Consult your pharmacist or local waste disposal company. 1981;3:115-20. Int J Dermatol. Accessibility For the best effect, take this antibiotic at evenly spaced times. Chronic pressure on the skin is probably involved in the onset of skin lesions in hand-foot eruptions induced by tyrosine kinase inhibitors (sorafenib and sutinib). Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. https://www.drugs.com/pro/clindamycin-capsules.html. Caspofungin, Clindamycin, Pneumocystis jirovecii pneumonia. Arch Dermatol. Medicines that interact with clindamycin may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with clindamycin. Measure the oral liquid correctly using the marked measuring spoon that comes with the package. Before Cone JB, Wetzel W. Toxic megacolon secondary to pseudomembranous colitis. The site is secure. While primaquine and pentamidine related adverse events cause frequently, and they are not available in most hospitals in China. government site. Call your doctor immediately if you develop a severe rash. doi: 10.1590/s0365-05962011000700023. privacy practices. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Consult your pharmacist or . The patient's symptoms developed 2 days after initiating oral clindamycin therapy for a tooth infection. There was a striking vertical distribution of skin lesions along the SD on the lateral sides of the abdomen (Figure 1, C). 2022 Jun;62(3):463-475. doi: 10.1007/s12016-021-08878-x. Trends of two indicators before and after treatment. Epub 2018 Jan 22. WebMD does not provide medical advice, diagnosis or treatment. If we combine this information with your protected Epub 2011 Jun 20. Mason SJ, O'Meara TF. HHS Vulnerability Disclosure, Help Amsden G.W., Foulds G., Thakker K. Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers. Store at room temperature away from light and moisture. Unfortunately, these results are not credible because we found out that she had stopped taking TMP/SMZ by herself for 2 days. Selected from data included with permission and copyrighted by First Databank, Inc. Zentralbl. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Major Pharmaceuticals. and works as a teacher in a local school. It is recommended that Caspofungin combined with clindamycin as an alternative in patients with treatment failure or intolerance to TMP/SMZ may achieve satisfactory therapeutic effects [11]. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Tian D, Mohan RJ, Stallings G. Drug rash with eosinophilia and systemic symptoms syndrome associated with clindamycin. The purpose of this case is to discuss the significance of monitoring TMP/SMZ concentrations in patients with PCP, demonstrate the efficacy of caspofungin combined with clindamycin in patients with TMP/SMZ intolerance or resistance and summarize 21 previously reported cases and our case. Chronic cutaneous lupus erythematosus and topical clindamycin solution Warning Oral route (Powder for Solution) Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening. What Are the Symptoms of Mantle Cell Lymphoma? If you miss a dose, take it as soon as you remember. If you notice other effects not listed above, contact your doctor or pharmacist. Although not all of these side effects may occur, if they do occur they may need medical attention. Drug information provided by: Merative, Micromedex. Careers, Unable to load your collection due to an error. Clindamycin in the treatment of soft tissue infections: a review of 15,019 patients. Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection with a difficult diagnosis, rapid progression, high mortality rate and poor prognosis. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. government site. Chronic cutaneous lupus erythematosus and topical clindamycin BMJ Case Rep. 2018 Sep 23;2018:bcr2018226728. Tu G.W., Ju M.J., Xu M. Combination of caspofungin and low-dose trimethoprim/sulfamethoxazole for the treatment of severe Pneumocystis jirovecii pneumonia in renal transplant recipients. The following information includes only the average doses of this medicine. You should refer to the prescribing information for clindamycin for a complete list of interactions. Available for Android and iOS devices. DICP. Clindamycin-Induced Sweet's Syndrome. Patch tests with clindamycin 1% in pet. Pneumocystis jiroveci pneumonia in patients with non-Hodgkin's lymphoma after Rituximab-containing regimen: two cases of report and literature review. Clindamycin - Infectious Diseases - Merck Manuals Professional Edition Chronic cutaneous lupus erythematosus of the face after 3 months of topical clindamycin 1%. We did not find reports in the literature of drug-induced cutaneous eruptions along the SD as a manifestation of a Koebner phenomenon. Kawachi Y, Taguchi S, Fujisawa Y, Furuta J, Nakamura Y, Ishii Y, Otsuka F. Pediatr Dermatol. Otherwise, call a poison control center right away. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The patient's symptoms persisted despite tooth extraction and continuance of antibiotic treatment with intravenous, then oral, clindamycin. For more severe infections, the dose is usually 16 to 25 mg per kg of body weight per day, divided into 3 or 4 equal doses. were also positive (+ on day 2 and day 4). Hypersensitivity reactions to other antibiotic classes, namely beta-lactams, sulfonamides, fluoroquinolones, and vancomycin, are discussed separately. Vanek J., Jirovec O. Parasitic pneumonia. Hidradenitis suppurativa associated with systemic lupus erythematosus - LWW Pseudomembranous colitis caused by topical clindamycin phosphate. The patient complained nausea after using TMP/SMZ and refused to take the drug anymore. Histopathology from two 4mm punch biopsies performed on separate occasions demonstrated features on H&E stain consistent with CCLE: epidermal atrophy and interface dermatitis with superficial perivascular, deep dermal and periadnexal lymphohistiocytic infiltrates containing some plasma cells. This content does not have an English version. Arch Dermatol. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). Drug-induced lupus erythematosus - MedlinePlus [Ref], Rare (less than 0.1%): Erythema multiforme, pruritus, Frequency not reported: Toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, bullous dermatitis, generalized mild to moderate morbilliform-like rash, acute generalized exanthematous pustulosis (AGEP), Sweet's Syndrome, Postmarketing reports: Serious cutaneous adverse reaction[Ref]. The patient stopped taking her own TMP/SMZ resulting in lower concentration of SMZ. Annaloro C., Della Volpe A., Usardi P., Lambertenghi Deliliers G. Caspofungin treatment of Pneumocystis pneumonia during conditioning for bone marrow transplantation. 2007;64:542-5. For more severe infections, 300 to 450 mg every 6 hours. The dosage is based on your medical condition and response to treatment. Rarely, may cause severe hypersensitivity reactions and anaphylaxis. A doctor may recommend. Current Controversies in Lupus Anticoagulant Detection - PMC Br J Dermatol. She was diagnosed as PCP by Grocott' Methenamine silver (GMS) staining of bronchoalveolar lavage fluid (BAL), and immediately received the combination strategy including TMP/SMZ (160/800mg tid)carboplatin (50mg qd with 70mg on day 1), clindamycin (0.6g q12h) and methylprednisolone (40mg q12h) to against Pneumocystis jirovecii. Take exactly as directed and for the duration intended. information is beneficial, we may combine your email and website usage information with For patients with PCP who require large doses of TMP/SMZ, serum concentrations should be detected to prevent excessive levels. PDF Antibiotic Prophylaxis 2017 Update - American Association of Endodontists Disclaimer. Leigh DA, Simmons K, Williams S. Gastrointestinal side effects following clindamycin and lincomycin treatment: a follow up study. The strategy of trimethoprim (TMP) 1520 mg/kg/day and sulfamethoxazole (SMZ) 75100mg/kg/day administered in three or four doses has long been standard treatment of PCP [1]. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Her rash had frustrated her for over 5 years, worsening with increased sun exposure. and transmitted securely. Miller Quidley A, Bookstaver PB, Gainey AB, Gainey MD. include protected health information. All rights reserved. If you are a Mayo Clinic patient, this could What is the best antibiotic to treat strep throat? It is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. The upper back, chest, shoulders and extensor arms are frequent sites. The site is secure. In addition, the trend of -glucan levels can be a predictor of therapeutic efficacy in PCP. Some strengths (eg, 150mg capsules) contain FD & C Yellow No. Drugs that inhibit CYP3A5=or 3A4 may cause increase blood concentrations of clindomeyin. Types of Topical Antibiotics for Acne. Peak concentrations are reached within 45 minutes; however, it may take up to 48 hours before infection-related symptoms start to abate. A very serious allergic reaction to this drug is rare. Cutaneous ADRs account for 10-30% of ADRs, and are most commonly due to antibiotics . 1998;32:309-11. Comedonic lupus: a rare presentation of discoid lupus erythematosus. Adverse drug reactions are common, particularly in hospital inpatients, with estimates of 2-3% of hospitalised patients experiencing an ADR, and one in 20 of them being potentially fatal. Data sources include IBM Watson Micromedex (updated 3 July 2023), Cerner Multum (updated 10 July 2023), ASHP (updated 10 July 2023) and others. Federal government websites often end in .gov or .mil. Clindamycin Hcl - Uses, Side Effects, and More - WebMD Patch tests were removed after the 2nd day, and late reactions were evaluated on day 2 and day 4. In a retrospective cohort study [2], a total of 67 adverse events (grade 3) were recorded according to the National Cancer Institute common terminology criteria for adverse events (CTCAE) version 4.03, and 6% patients discontinued TMP/SMX therapy because of severe adverse events. dermatology; skin. Careers. Check with your doctor immediately if any of the following side effects occur while taking clindamycin: Applies to clindamycin: compounding powder, injectable solution, intravenous solution, oral capsule, oral powder for reconstitution. It has a bacteriostatic effect which means it stops bacteria from reproducing but doesn't necessarily kill them. Beltz K., Kramm C.M., Laws H.J., Schroten H., Wessalowski R., Gbel U. As for TMP, individual differences could not be excluded. She was finally in good condition with her -glucan decreased to 89.0 pg/ml, LDH to 691 U/L before she was discharged from hospital (Fig. Report any instances of severe or persistent diarrhea, occurring either during clindamycin administration or within a few months following discontinuation to your doctor. Effective against several gram-positive and anaerobic bacteria, including susceptible strains of, For infections caused by susceptible strains of. However, the number of cases alone using caspofungin is small and the efficacy remains uncertain, we can only attempted a new strategy of caspofungin combined with clindamycin as this patient was intolerant of TMP/SMZ and primaquine was not available in Chinese hospitals. The average household teaspoon may not hold the right amount of liquid. prednisone, amoxicillin, doxycycline, ciprofloxacin, metronidazole, azithromycin, cephalexin, clindamycin, levofloxacin, dexamethasone. Tell your doctor about any other medications you take, including those brought over the counter from a pharmacy, supermarket, or health store. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Common triggers for lupus | Lupus Foundation of America Clindamycin is secreted into breast milk and may potentially cause adverse effects on the GI flora of breast-fed infants. Bethesda, MD 20894, Web Policies Please enable it to take advantage of the complete set of features! Be cautious when using in patients with kidney or liver disease. Clindamycin (Oral Route) Proper Use - Mayo Clinic This condition may occur during treatment or weeks to months after treatment has stopped. Efficacy of caspofungin combined with clindamycin for Pneumocystis jirovecii pneumonia in a systemic lupus erythematosus patient: A case report and literature review.
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